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Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling

Aberrant activation of sonic Hegdehog (SHH) signaling has been found to disrupt cellular differentiation in many human cancers and to increase proliferation. The SHH pathway is known to cross-talk with EGFR dependent signaling. Recent studies experimentally addressed this interplay in Daoy cells, wh...

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Vydáno v:PLoS One
Hlavní autoři: Fröhlich, Holger, Bahamondez, Gloria, Götschel, Frank, Korf, Ulrike
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646463/
https://ncbi.nlm.nih.gov/pubmed/26571415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142646
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