Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport

The cholesterol storage disorder Niemann-Pick type C (NPC) disease is caused by defects in either of two late endosomal/lysosomal proteins, NPC1 and NPC2. NPC2 is a 16-kDa soluble protein that binds cholesterol in a 1:1 stoichiometry and can transfer cholesterol between membranes by a mechanism that...

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發表在:J Biol Chem
Main Authors: McCauliff, Leslie A., Xu, Zhi, Li, Ran, Kodukula, Sarala, Ko, Dennis C., Scott, Matthew P., Kahn, Peter C., Storch, Judith
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2015
主題:
Molecular Bases of Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646368/
https://ncbi.nlm.nih.gov/pubmed/26296895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.667469
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