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Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in the genes encoding NPC1 or NPC2. We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to and from mo...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6855803/ https://ncbi.nlm.nih.gov/pubmed/31580258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50832 |
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