Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects in the genes encoding NPC1 or NPC2. We previously reported the dramatic stimulation of NPC2 cholesterol transport rates to and from mo...

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Vydáno v:eLife
Hlavní autoři: McCauliff, Leslie A, Langan, Annette, Li, Ran, Ilnytska, Olga, Bose, Debosreeta, Waghalter, Miriam, Lai, Kimberly, Kahn, Peter C, Storch, Judith
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855803/
https://ncbi.nlm.nih.gov/pubmed/31580258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50832
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