Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ

Phospholipase C-epsilon (PLCϵ) plays a critical role in G-protein-coupled receptor-mediated inflammation. In addition to its ability to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol, PLCϵ, unlike the other phospholipase C family members, is activated in a sustained m...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Dusaban, Stephanie S., Kunkel, Maya T., Smrcka, Alan V., Brown, Joan Heller
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646330/
https://ncbi.nlm.nih.gov/pubmed/26350460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676098
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