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Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592
SAMHD1 is a cellular protein that plays key roles in HIV-1 restriction and regulation of cellular dNTP levels. Mutations in SAMHD1 are also implicated in the pathogenesis of chronic lymphocytic leukemia and Aicardi-Goutières syndrome. The anti-HIV-1 activity of SAMHD1 is negatively modulated by phos...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646291/ https://ncbi.nlm.nih.gov/pubmed/26294762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677435 |
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