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Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592

SAMHD1 is a cellular protein that plays key roles in HIV-1 restriction and regulation of cellular dNTP levels. Mutations in SAMHD1 are also implicated in the pathogenesis of chronic lymphocytic leukemia and Aicardi-Goutières syndrome. The anti-HIV-1 activity of SAMHD1 is negatively modulated by phos...

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Pubblicato in:J Biol Chem
Autori principali: Tang, Chenxiang, Ji, Xiaoyun, Wu, Li, Xiong, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646291/
https://ncbi.nlm.nih.gov/pubmed/26294762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677435
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