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Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to form the AIM2 inflammasome, which leads to proteolytic maturation of cytokines a...
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| Publicat a: | Cell Discov |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646227/ https://ncbi.nlm.nih.gov/pubmed/26583071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.13 |
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