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The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism
The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting pathogen clearance by urine excretion. Despite its critical role in the innate immune response against urinary tract infections, th...
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| Publicat a: | eLife |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7486124/ https://ncbi.nlm.nih.gov/pubmed/32815518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60265 |
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