The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting pathogen clearance by urine excretion. Despite its critical role in the innate immune response against urinary tract infections, th...

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Bibliographic Details
Published in:eLife
Main Authors: Stanisich, Jessica J, Zyla, Dawid S, Afanasyev, Pavel, Xu, Jingwei, Kipp, Anne, Olinger, Eric, Devuyst, Olivier, Pilhofer, Martin, Boehringer, Daniel, Glockshuber, Rudi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486124/
https://ncbi.nlm.nih.gov/pubmed/32815518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60265
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