Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity. We found that the PrgJ-NAIP2-NLRC4 inflammasome is assemble...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Zhang, Liman, Chen, Shuobing, Ruan, Jianbin, Wu, Jiayi, Tong, Alexander B., Yin, Qian, Li, Yang, David, Liron, Lu, Alvin, Wang, Wei Li, Marks, Carolyn, Ouyang, Qi, Zhang, Xinzheng, Mao, Youdong, Wu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640189/
https://ncbi.nlm.nih.gov/pubmed/26449474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac5789
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