Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2

Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to form the AIM2 inflammasome, which leads to proteolytic maturation of cytokines a...

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Bibliographic Details
Published in:Cell Discov
Main Authors: Lu, Alvin, Li, Yang, Yin, Qian, Ruan, Jianbin, Yu, Xiong, Egelman, Edward, Wu, Hao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646227/
https://ncbi.nlm.nih.gov/pubmed/26583071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.13
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