Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis

Frequent alteration of upstream proto-oncogenes and tumor suppressor genes activates mechanistic target of rapamycin (mTOR) and causes cancer. However, the downstream effectors of mTOR remain largely elusive. Here we report that brain-expressed X-linked 2 (BEX2) is a novel downstream effector of mTO...

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Vydáno v:J Biol Chem
Hlavní autoři: Hu, Zhongdong, Wang, Ying, Huang, Fuqiang, Chen, Rongrong, Li, Chunjia, Wang, Fang, Goto, June, Kwiatkowski, David J., Wdzieczak-Bakala, Joanna, Tu, Pengfei, Liu, Jianmiao, Zha, Xiaojun, Zhang, Hongbing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646217/
https://ncbi.nlm.nih.gov/pubmed/26296882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665208
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