ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response

The Fanconi anemia protein PALB2, also known as FANCN, protects genome integrity by regulating DNA repair and cell cycle checkpoints. Exactly how PALB2 functions may be temporally coupled with detection and signaling of DNA damage is not known. Intriguingly, we found that PALB2 is transformed into a...

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Udgivet i:J Biol Chem
Main Authors: Guo, Yingying, Feng, Wanjuan, Sy, Shirley M. H., Huen, Michael S. Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646007/
https://ncbi.nlm.nih.gov/pubmed/26420486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672626
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