Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor

Entry inhibitors represent a potent class of antiretroviral drugs that target a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein. Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral adaptation to u...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Jiang, Xiaowei, Feyertag, Felix, Meehan, Conor J., McCormack, Grace P., Travers, Simon A., Craig, Charles, Westby, Mike, Lewis, Marilyn, Robertson, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645647/
https://ncbi.nlm.nih.gov/pubmed/26339063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01384-15
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