Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry

Maraviroc is a CCR5 antagonist in clinical development as one of a new class of antiretrovirals targeting human immunodeficiency virus type 1 (HIV-1) coreceptor binding. We investigated the mechanism of HIV resistance to maraviroc by using in vitro sequential passage and site-directed mutagenesis. S...

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Detalhes bibliográficos
Main Authors: Westby, Mike, Smith-Burchnell, Caroline, Mori, Julie, Lewis, Marilyn, Mosley, Michael, Stockdale, Mark, Dorr, Patrick, Ciaramella, Giuseppe, Perros, Manos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865946/
https://ncbi.nlm.nih.gov/pubmed/17182681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02006-06
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