HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism

Maraviroc (MVC) inhibits the entry of human immunodeficiency virus type 1 (HIV-1) by binding to and modifying the conformation of the CCR5 extracellular loops (ECLs). Resistance to MVC results from alterations in the HIV-1 gp120 envelope glycoproteins (Env) enabling recognition of the drug-bound con...

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Bibliographische Detailangaben
Hauptverfasser: Roche, Michael, Jakobsen, Martin R., Sterjovski, Jasminka, Ellett, Anne, Posta, Filippo, Lee, Benhur, Jubb, Becky, Westby, Mike, Lewin, Sharon R., Ramsland, Paul A., Churchill, Melissa J., Gorry, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126252/
https://ncbi.nlm.nih.gov/pubmed/21345957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00106-11
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