Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhibitor (IαI), which functions to increase its avidity for le...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Lauer, Mark E., Majors, Alana K., Comhair, Suzy, Ruple, Lisa M., Matuska, Brittany, Subramanian, Ahila, Farver, Carol, Dworski, Ryszard, Grandon, Deepa, Laskowski, Dan, Dweik, Raed A., Erzurum, Serpil C., Hascall, Vincent C., Aronica, Mark A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Glycobiology and Extracellular Matrices
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645592/
https://ncbi.nlm.nih.gov/pubmed/26209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663823
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