Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhibitor (IαI), which functions to increase its avidity for le...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Lauer, Mark E., Majors, Alana K., Comhair, Suzy, Ruple, Lisa M., Matuska, Brittany, Subramanian, Ahila, Farver, Carol, Dworski, Ryszard, Grandon, Deepa, Laskowski, Dan, Dweik, Raed A., Erzurum, Serpil C., Hascall, Vincent C., Aronica, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645592/
https://ncbi.nlm.nih.gov/pubmed/26209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663823
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