Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhibitor (IαI), which functions to increase its avidity for le...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lauer, Mark E., Majors, Alana K., Comhair, Suzy, Ruple, Lisa M., Matuska, Brittany, Subramanian, Ahila, Farver, Carol, Dworski, Ryszard, Grandon, Deepa, Laskowski, Dan, Dweik, Raed A., Erzurum, Serpil C., Hascall, Vincent C., Aronica, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645592/
https://ncbi.nlm.nih.gov/pubmed/26209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663823
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