Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhibitor (IαI), which functions to increase its avidity for le...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Lauer, Mark E., Majors, Alana K., Comhair, Suzy, Ruple, Lisa M., Matuska, Brittany, Subramanian, Ahila, Farver, Carol, Dworski, Ryszard, Grandon, Deepa, Laskowski, Dan, Dweik, Raed A., Erzurum, Serpil C., Hascall, Vincent C., Aronica, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645592/
https://ncbi.nlm.nih.gov/pubmed/26209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663823
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