Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation

Hyaluronan (HA) is a large (>1500 kDa) polysaccharide of the extracellular matrix that has been linked to severity and inflammation in asthma. During inflammation, HA becomes covalently modified with heavy chains (HC-HA) from inter-α-inhibitor (IαI), which functions to increase its avidity for le...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Lauer, Mark E., Majors, Alana K., Comhair, Suzy, Ruple, Lisa M., Matuska, Brittany, Subramanian, Ahila, Farver, Carol, Dworski, Ryszard, Grandon, Deepa, Laskowski, Dan, Dweik, Raed A., Erzurum, Serpil C., Hascall, Vincent C., Aronica, Mark A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Glycobiology and Extracellular Matrices
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645592/
https://ncbi.nlm.nih.gov/pubmed/26209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663823
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