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Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation

Methotrexate (MTX) is an anti-folate that inhibits de novo purine and thymidine nucleotide synthesis. MTX induces death in rapidly replicating cells and is used in the treatment of multiple cancers. MTX inhibits thymidine synthesis by targeting dihydrofolate reductase (DHFR) and thymidylate synthase...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rushworth, David, Mathews, Amber, Alpert, Amir, Cooper, Laurence J. N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645590/
https://ncbi.nlm.nih.gov/pubmed/26242737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C115.671123
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