Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

We have investigated factors that influence the production of native-like soluble, recombinant trimers based on the env genes of two isolates of human immunodeficiency virus type 1 (HIV-1), specifically 92UG037.8 (clade A) and CZA97.012 (clade C). When the recombinant trimers based on the env genes...

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Veröffentlicht in:J Virol
Hauptverfasser: Ringe, Rajesh P., Yasmeen, Anila, Ozorowski, Gabriel, Go, Eden P., Pritchard, Laura K., Guttman, Miklos, Ketas, Thomas A., Cottrell, Christopher A., Wilson, Ian A., Sanders, Rogier W., Cupo, Albert, Crispin, Max, Lee, Kelly K., Desaire, Heather, Ward, Andrew B., Klasse, P. J., Moore, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645310/
https://ncbi.nlm.nih.gov/pubmed/26311893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01768-15
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