Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

[Image: see text] Peroxidic antimalarial agents including the sequiterpene artemisinins and the synthetic 1,2,4-trioxolanes function via initial intraparasitic reduction of an endoperoxide bond. By chemically coupling this reduction to release of a tethered drug species it is possible to confer two...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Lauterwasser, Erica M. W., Fontaine, Shaun D., Li, Hao, Gut, Jiri, Katneni, Kasiram, Charman, Susan A., Rosenthal, Philip J., Bogyo, Matthew, Renslo, Adam R.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2015
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645246/
https://ncbi.nlm.nih.gov/pubmed/26617969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00296
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