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Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase

Excess nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is implicated in neurodegenerative disorders. As a result, inhibition of nNOS and reduction of NO levels is desirable therapeutically, but many nNOS inhibitors are poorly bioavailable. Promising members of our previously repo...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Cinelli, Maris A., Li, Huiying, Pensa, Anthony V., Kang, Soosung, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644118/
https://ncbi.nlm.nih.gov/pubmed/26469213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01330
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