Inhibition of WNK3 kinase signaling reduces brain damage and accelerates neurological recovery after stroke

BACKGROUND AND PURPOSE: WNK kinases, including WNK3, and the associated downstream SPAK and OSR1 kinases, comprise an important signaling cascade that regulates the cation-chloride cotransporters. Ischemia-induced stimulation of the bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays a...

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Publicado no:Stroke
Main Authors: Begum, Gulnaz, Yuan, Hui, Kahle, Kristopher T., Li, Liaoliao, Wang, Shaoxia, Shi, Yejie, Shmukler, Boris E., Yang, Sung-Sen, Lin, Shih-Hua, Alper, Seth L., Sun, Dandan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643659/
https://ncbi.nlm.nih.gov/pubmed/26069258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.008939
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