Inhibition of Na(+)-K(+)-2Cl(−) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells

The hallmark of apoptosis is a significant reduction in cell volume (AVD) resulting from loss of K(+)(i) and Cl(−)(i). Loss of cell volume and lowering of ionic strength of intracellular K(+) and Cl(−) occur before any other detectable characteristics of apoptosis. In the present study, temozolomide...

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Hauptverfasser: Algharabli, Jehad, Kintner, Douglas B., Wang, Qiwei, Begum, Gulnaz, Clark, Paul A., Yang, Sung-Sen, Lin, Shih-Hua, Kahle, Kristopher T., Kuo, John S., Sun, Dandan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603147/
https://ncbi.nlm.nih.gov/pubmed/22759954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000339047
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