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Inhibition of Na(+)-K(+)-2Cl(−) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells
The hallmark of apoptosis is a significant reduction in cell volume (AVD) resulting from loss of K(+)(i) and Cl(−)(i). Loss of cell volume and lowering of ionic strength of intracellular K(+) and Cl(−) occur before any other detectable characteristics of apoptosis. In the present study, temozolomide...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603147/ https://ncbi.nlm.nih.gov/pubmed/22759954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000339047 |
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