Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism

While gene mutations in the amyloid precursor protein (APP) and the presenilins lead to an accumulation of the amyloid β-peptide (Aβ) in the brain causing neurodegeneration and familial Alzheimer's disease (AD), over 95% of all AD cases are sporadic. Despite the pathologies being indistinguisha...

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Detalles Bibliográficos
Publicado en:Front Neurosci
Autores principales: Kerridge, Caroline, Kozlova, Daria I., Nalivaeva, Natalia N., Turner, Anthony J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Psychiatry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643132/
https://ncbi.nlm.nih.gov/pubmed/26617481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2015.00426
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