Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder of mid-life onset characterized by involuntary movements and progressive cognitive decline caused by a CAG repeat expansion in exon 1 of the Huntingtin (Htt) gene. Neuronal DNA damage is one of the major features of neurod...

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Pubblicato in:Mol Neurobiol
Autori principali: Jeon, Gye Sun, Kim, Ki Yoon, Hwang, Yu Jin, Jung, Min-Kyung, An, Sungkwan, Ouchi, Mutsuko, Ouchi, Toru, Kowall, Neil, Lee, Junghee, Ryu, Hoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642996/
https://ncbi.nlm.nih.gov/pubmed/22580959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-012-8274-9
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