Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis

Activation of hepatic stellate cells (HSCs) by transforming growth factor-β1 (TGF-β1) initiates HBV-associated fibrogenesis. The mechanism of TGF-β1 modulating HSC activation is not fully uncovered. We hypothesized a positive feedback signaling loop of TGF-β1-CD147 promoting liver fibrogenesis by ac...

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Publicado en:Sci Rep
Autores principales: Li, Hai-Yan, Ju, Di, Zhang, Da-Wei, Li, Hao, Kong, Ling-Min, Guo, Yanhai, Li, Can, Wang, Xi-Long, Chen, Zhi-Nan, Bian, Huijie
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642271/
https://ncbi.nlm.nih.gov/pubmed/26559755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16552
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