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Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis
Activation of hepatic stellate cells (HSCs) by transforming growth factor-β1 (TGF-β1) initiates HBV-associated fibrogenesis. The mechanism of TGF-β1 modulating HSC activation is not fully uncovered. We hypothesized a positive feedback signaling loop of TGF-β1-CD147 promoting liver fibrogenesis by ac...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642271/ https://ncbi.nlm.nih.gov/pubmed/26559755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16552 |
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