Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High Throughput Screening

The target of this study, the PfM18 aspartyl aminopeptidase (PfM18AAP), is the only AAP present in the genome of the malaria parasite Plasmodium falciparum. PfM18AAP is a metallo-exopeptidase that exclusively cleaves N-terminal acidic amino acids glutamate and aspartate. It is expressed in parasite...

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Detalhes bibliográficos
Publicado no:J Biomol Screen
Main Authors: Spicer, Timothy, Fernandez-Vega, Virneliz, Chase, Peter, Scampavia, Louis, To, Joyce, Dalton, John P, Da Silva, Fabio L, Skinner-Adams, Tina S, Gardiner, Donald L, Trenholme, Katharine R, Brown, Christopher L, Ghosh, Partha, Porubsky, Patrick, Wang, Jenna L, Whipple, David A, Schoenen, Frank J, Hodder, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641816/
https://ncbi.nlm.nih.gov/pubmed/24619116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114525852
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