Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High Throughput Screening

The target of this study, the PfM18 aspartyl aminopeptidase (PfM18AAP), is the only AAP present in the genome of the malaria parasite Plasmodium falciparum. PfM18AAP is a metallo-exopeptidase that exclusively cleaves N-terminal acidic amino acids glutamate and aspartate. It is expressed in parasite...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biomol Screen
Prif Awduron: Spicer, Timothy, Fernandez-Vega, Virneliz, Chase, Peter, Scampavia, Louis, To, Joyce, Dalton, John P, Da Silva, Fabio L, Skinner-Adams, Tina S, Gardiner, Donald L, Trenholme, Katharine R, Brown, Christopher L, Ghosh, Partha, Porubsky, Patrick, Wang, Jenna L, Whipple, David A, Schoenen, Frank J, Hodder, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641816/
https://ncbi.nlm.nih.gov/pubmed/24619116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114525852
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg