Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls by targeting distinct cellular glycans. We demonstrate that a single amino acid substitution in a banana lectin, replacing histidine 84 with a threonine, significantly reduces its mitogenicity while preser...

Full description

Saved in:
Bibliographic Details
Published in:Cell
Main Authors: Swanson, Michael D., Boudreaux, Daniel M., Salmon, Loïc, Chugh, Jeetender, Winter, Harry C., Meagher, Jennifer L., André, Sabine, Murphy, Paul V., Oscarson, Stefan, Roy, René, King, Steven, Kaplan, Mark H., Goldstein, Irwin J., Tarbet, E. Bart, Hurst, Brett L., Smee, Donald F., de la Fuente, Cynthia, Hoffmann, Hans-Heinrich, Xue, Yi, Rice, Charles M., Schols, Dominique, Garcia, J. Victor, Stuckey, Jeanne A., Gabius, Hans-Joachim, Al-Hashimi, Hashim M., Markovitz, David M.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641746/
https://ncbi.nlm.nih.gov/pubmed/26496612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.056
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items