Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls by targeting distinct cellular glycans. We demonstrate that a single amino acid substitution in a banana lectin, replacing histidine 84 with a threonine, significantly reduces its mitogenicity while preser...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Swanson, Michael D., Boudreaux, Daniel M., Salmon, Loïc, Chugh, Jeetender, Winter, Harry C., Meagher, Jennifer L., André, Sabine, Murphy, Paul V., Oscarson, Stefan, Roy, René, King, Steven, Kaplan, Mark H., Goldstein, Irwin J., Tarbet, E. Bart, Hurst, Brett L., Smee, Donald F., de la Fuente, Cynthia, Hoffmann, Hans-Heinrich, Xue, Yi, Rice, Charles M., Schols, Dominique, Garcia, J. Victor, Stuckey, Jeanne A., Gabius, Hans-Joachim, Al-Hashimi, Hashim M., Markovitz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641746/
https://ncbi.nlm.nih.gov/pubmed/26496612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.056
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