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Fluorinated Carbohydrates as Lectin Ligands: Dissecting Glycan-Cyanovirin Interactions by (19)F-NMR

NMR spectroscopy and ITC are powerful methods to investigate ligand-protein interactions. Here, we present a versatile and sensitive fluorine NMR approach that exploits the (19)F nucleus of (19)F labeled carbohydrates as a sensor to study glycan binding to lectins. Our approach is illustrated with t...

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Bibliografische gegevens
Hoofdauteurs: Matei, Elena, André, Sabine, Glinschert, Anja, Infantino, Angela Simona, Oscarson, Stefan, Gabius, Hans-Joachim, Gronenborn, Angela M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796943/
https://ncbi.nlm.nih.gov/pubmed/23447543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201204070
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