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A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus
We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001–1013), which corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized pJAK2(1001–1013) inhibits SOCS1 and SOCS3. SOCS1...
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| Pubblicato in: | Front Immunol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4641302/ https://ncbi.nlm.nih.gov/pubmed/26617608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00574 |
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