A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus

We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001–1013), which corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized pJAK2(1001–1013) inhibits SOCS1 and SOCS3. SOCS1...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ahmed, Chulbul M., Dabelic, Rea, Bedoya, Simone Kennedy, Larkin, Joseph, Johnson, Howard M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641302/
https://ncbi.nlm.nih.gov/pubmed/26617608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00574
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