TNFRSF13B hemizygosity reveals TACI haploinsufficiency at later stages of B-cell development

BACKGROUND: Heterozygous C104R or A181E TNFRSF13B mutations impair the removal of autoreactive B cells, weaken B-cell activation and convey to common variable immune deficiency (CVID) patients an increased risk for autoimmunity. How mutant TACI influences wildtype TACI function is unclear; different...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Romberg, Neil, Virdee, Manmeet, Chamberlain, Nicolas, Oe, Tyler, Schickel, Jean-Nicolas, Perkins, Tiffany, Cantaert, Tineke, Rachid, Rima, Rosengren, Sally, Palazzo, Regina, Geha, Raif, Cunningham-Rundles, Charlotte, Meffre, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641026/
https://ncbi.nlm.nih.gov/pubmed/26100089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.012
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