CVID-associated TACI mutations affect autoreactive B cell selection and activation

Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity. Heterozygous mutations in the gene encoding the tumor necrosis factor receptor superfamily member TACI are associated with...

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Autores principales: Romberg, Neil, Chamberlain, Nicolas, Saadoun, David, Gentile, Maurizio, Kinnunen, Tuure, Ng, Yen Shing, Virdee, Manmeet, Menard, Laurence, Cantaert, Tineke, Morbach, Henner, Rachid, Rima, Martinez-Pomar, Natalia, Matamoros, Nuria, Geha, Raif, Grimbacher, Bodo, Cerutti, Andrea, Cunningham-Rundles, Charlotte, Meffre, Eric
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786721/
https://ncbi.nlm.nih.gov/pubmed/24051380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69854
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