Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)

B cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R, which abolishes ligand binding, fail to produce Igs in response to TACI ligand. It is not known whether this is due to haploinsufficiency or...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Garibyan, Lilit, Lobito, Adrian A., Siegel, Richard M., Call, Matthew E., Wucherpfennig, Kai W., Geha, Raif S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865037/
https://ncbi.nlm.nih.gov/pubmed/17492055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31023
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker