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Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)

B cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R, which abolishes ligand binding, fail to produce Igs in response to TACI ligand. It is not known whether this is due to haploinsufficiency or...

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Detalhes bibliográficos
Main Authors: Garibyan, Lilit, Lobito, Adrian A., Siegel, Richard M., Call, Matthew E., Wucherpfennig, Kai W., Geha, Raif S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865037/
https://ncbi.nlm.nih.gov/pubmed/17492055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31023
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