Dystrophin–glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling

Patients deficient in dystrophin, a protein that links the cytoskeleton to the extracellular matrix via the dystrophin–glycoprotein complex (DGC), exhibit muscular dystrophy, cardiomyopathy, and impaired muscle nitric oxide (NO) production. We used live-cell NO imaging and in vitro cyclic stretch of...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Garbincius, Joanne F., Michele, Daniel E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640723/
https://ncbi.nlm.nih.gov/pubmed/26483453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512991112
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