Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.
In cultured rat and human pancreatic islets, glucose stimulated transcription of the rat insulin I gene through the mini-enhancer (FF) located between residues -196 and -247. The glucose-sensitive element was delineated to the region -193 to -227. The mini-enhancer bound islet nuclear proteins to fo...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1993
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46406/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8483904/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.9.3865 |
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