Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.

In cultured rat and human pancreatic islets, glucose stimulated transcription of the rat insulin I gene through the mini-enhancer (FF) located between residues -196 and -247. The glucose-sensitive element was delineated to the region -193 to -227. The mini-enhancer bound islet nuclear proteins to fo...

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Bibliographic Details
Main Authors: Melloul, D, Ben-Neriah, Y, Cerasi, E
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC46406/
https://ncbi.nlm.nih.gov/pubmed/8483904
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