Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors

Despite aggressive therapy, existing treatments offer poor prognosis for glioblastoma multiforme patients, in part due to poor penetration of most drugs across the blood–brain barrier (BBB). We propose a minimal-invasive combined treatment approach consisting of local BBB disruption in the tumor in...

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Dades bibliogràfiques
Publicat a:J Cereb Blood Flow Metab
Autors principals: Cooper, Itzik, Last, David, Guez, David, Sharabi, Shirley, Elhaik Goldman, Shirin, Lubitz, Irit, Daniels, Dianne, Salomon, Sharona, Tamar, Gregory, Tamir, Tzur, Mardor, Ronni, Fridkin, Mati, Shechter, Yoram, Mardor, Yael
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640261/
https://ncbi.nlm.nih.gov/pubmed/25669901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.6
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