Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors

Despite aggressive therapy, existing treatments offer poor prognosis for glioblastoma multiforme patients, in part due to poor penetration of most drugs across the blood–brain barrier (BBB). We propose a minimal-invasive combined treatment approach consisting of local BBB disruption in the tumor in...

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Detalles Bibliográficos
Publicado en:J Cereb Blood Flow Metab
Autores principales: Cooper, Itzik, Last, David, Guez, David, Sharabi, Shirley, Elhaik Goldman, Shirin, Lubitz, Irit, Daniels, Dianne, Salomon, Sharona, Tamar, Gregory, Tamir, Tzur, Mardor, Ronni, Fridkin, Mati, Shechter, Yoram, Mardor, Yael
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640261/
https://ncbi.nlm.nih.gov/pubmed/25669901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.6
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