Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors

Despite aggressive therapy, existing treatments offer poor prognosis for glioblastoma multiforme patients, in part due to poor penetration of most drugs across the blood–brain barrier (BBB). We propose a minimal-invasive combined treatment approach consisting of local BBB disruption in the tumor in...

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Dettagli Bibliografici
Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Cooper, Itzik, Last, David, Guez, David, Sharabi, Shirley, Elhaik Goldman, Shirin, Lubitz, Irit, Daniels, Dianne, Salomon, Sharona, Tamar, Gregory, Tamir, Tzur, Mardor, Ronni, Fridkin, Mati, Shechter, Yoram, Mardor, Yael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640261/
https://ncbi.nlm.nih.gov/pubmed/25669901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.6
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