Combined local blood–brain barrier opening and systemic methotrexate for the treatment of brain tumors

Despite aggressive therapy, existing treatments offer poor prognosis for glioblastoma multiforme patients, in part due to poor penetration of most drugs across the blood–brain barrier (BBB). We propose a minimal-invasive combined treatment approach consisting of local BBB disruption in the tumor in...

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Détails bibliographiques
Publié dans:J Cereb Blood Flow Metab
Auteurs principaux: Cooper, Itzik, Last, David, Guez, David, Sharabi, Shirley, Elhaik Goldman, Shirin, Lubitz, Irit, Daniels, Dianne, Salomon, Sharona, Tamar, Gregory, Tamir, Tzur, Mardor, Ronni, Fridkin, Mati, Shechter, Yoram, Mardor, Yael
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640261/
https://ncbi.nlm.nih.gov/pubmed/25669901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.6
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