Bub3–BubR1-dependent sequestration of Cdc20(Fizzy) at DNA breaks facilitates the correct segregation of broken chromosomes

The presence of DNA double-strand breaks during mitosis is particularly challenging for the cell, as it produces broken chromosomes lacking a centromere. This situation can cause genomic instability resulting from improper segregation of the broken fragments into daughter cells. We recently uncovere...

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Vydáno v:J Cell Biol
Hlavní autoři: Derive, Nicolas, Landmann, Cedric, Montembault, Emilie, Claverie, Marie-Charlotte, Pierre-Elies, Priscillia, Goutte-Gattat, Damien, Founounou, Nabila, McCusker, Derek, Royou, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639866/
https://ncbi.nlm.nih.gov/pubmed/26553926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504059
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