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Intramedullary megakaryocytes internalize released platelet factor 4 (PF4) and store it in alpha granules
BACKGROUND: Megakaryocytes express and store platelet factor 4 (PF4) in alpha-granules. In vivo, PF4 is a clinically-relevant, negative regulator of megakaryopoiesis and hematopoietic stem cell (HSC) replication. These findings would suggest a regulated source of free intramedullary PF4. OBJECTIVES:...
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| Publié dans: | J Thromb Haemost |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4638179/ https://ncbi.nlm.nih.gov/pubmed/26256688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13069 |
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